New photos of Mesquite !

Mesquite lives in Beautiful British Columbia with his co-owner, Debbie Cornell-Charneski, a professional handler. Mesquite, born Aug 8, 2008, is sired by Mexican Champion Allende out of the Multi-Champion Techutli.
Quito, as he is fondly referred to, has the excellent blend of the elegant substance required of a standard Xolo. His almond shaped amber eyes are set into a correctly proportioned head which is set onto an elegantly arched neck. His ears are well set, shaped and compliment his head. With proper height to body length ratio, level topline, slightly sloping croup and correctly set and carried tail, he is a lovely example of the breed.

A special message from Barbara………

Nine years ago today, March 25th, a terrified and abused little nekked dog stepped out of a rescue lady’s van and wrapped his little Xolo hands around my heart. Wearing an oversized baggy sweater he came slinking up to snatch an offered bribe, darting back quickly in fear.  Suddenly he exploded and a squirmish ensued as the rescue lady’s Whippet also wanted that peace offering.  With that introduction and an exchange of $66.50 in cash for a what was to become a “special needs” Xolo, we left the truck stop rendezvous and headed home with our scared little rescue. 
The dog with many names!  First, “Snoopy,” his original name when turned into the shelter because his owners “were moving” — aka  dumping a problem dog they
probably bought on a whim;  next, the “Walla Walla Crestie” because he was turned in as a Chinese Crested; then, “The Walla Walla Xolo”, his rescue name given by the many who campaigned to spare him from pending execution as it was realized that he was in fact, a Xolo, not a Crestie; and NOW Gwinn-Dell9 9s Don Quixote Mex CGC NAC O-NAC S-NAC NCC O-NCC S-NCC O-CC OAC  O-OAC   NJC  O-NJC  S-NJC  OJC  O-OJC S-OJC NJS-N  NGC  O-NGC  S-NGC TN-N O-TN-N S-TN-N  TN-O O-TN-O S-TN-O WV-N  O-WV-N  S-WV-N TG-N O-TG-N  S-TG-N  TG-O O-TG-O AG-N  OGC EJC S-TN-O WV-O S-TG-N  RN RS-N GS-N CL3-R CL3-F CL3-H CL3-S PS1 PJ1 TBAD TG-1 TIAD NAJ NA OA OAJ AJX O-OCC-V, his agility name. . . . This  is my beloved Quixote aka The Rotten Rubber Dog aka The=2 0RRD. 
A few hours from execution, Quixote’s doom was scheduled and I had to plead for them to spare him.  They had wanted to euthanize him as soon as he arrived because20he was hairless.  His 3 week stay netted no potential owners; his abuse, terror, and subsequent hatred for people was evident, and he, like many of the shelter dogs that spring, was terribly ill.  In addition, his execution was already pending when I called, e-mailed, and begged for his life.  Reluctantly they relented, emphasizing that I must pay cash.  Thus we headed to eastern Oregon to meet the kind rescue lady and the “Walla Walla Xolo.” 
Quixote grew from a fearful, people hating mistreated rescue to one of the breed’s most famous.  He is the first of his breed to earn an Elite agility title, the first Xolo to earn a NADAC Triple Superior, the first Xolo to make #1 Elite Jumpers Xolo, the first Xolo to earn an AKC Excellent title . . . . Once a few hours away from execution, he has become an outstanding ambassador for the breed.  He loves people and educates thousands about this wonderful breed.  His fan club stretches across the world and his little Xolo antics entertain and endear him to all who meet him.  From rags to riches, Quixote’s picture appeared in hi s homeland on a Xolo display at Mexico’s World Dog show.
Thanks to Quixote I found this wonderful breed. Thanks to Quixote we are hooked on the breed and are owned by 5 RRDs.  Thanks to Quixote the breed has a registry for Xolos in the USA, as starting with a cardboard box and a pile of pedigrees with names in a strange language, I developed a database which tracks coat type, size, and heritage and documents the history of Xolo lineage in the USA.  Thanks to Quixote, I found agility, our passion and found many dear friends. Thanks to Quixote I have Xolo friends throughout the world.  One dear friend is Gary Armitage who, through Crestie Care, lead the campaign to save the Walla Walla death row inmate.  Quixote’s “Uncle Gary” was instrumental in keeping him alive.  Thanks to Sharon, the Borzoi/Whippet lady who fostered him and met us at that truck stop. 
I found my heart-dog and best friend.  This weekend, we celebrate with 3 days of running in AKC Excellent agility.  Quixote, a little “throw-away” death row dog has helped me realize the impossible dream.
 ~ Barbara
Gwinn-Dell Xoloitzcuintle & Irish Wolfhounds & a couple of goofy Goldens

A short report on the recent article in Science magazine about the hairless gene in dogs.

The title of the article is “A Mutation in Hairless Dogs Implicates FOX13 in Ectodermal Development” The researchers are from Sweden, Finland, Swizerland and the Broad Institute of Harvard U. and  MIT The people from the University of Bern in Swizerland seem to be the prime researchers. They are Cord Drogemuller, Elinor Karlsson, Marjo K. Hytonen, Gaudenz Dolf, Kirsi Sainio, Hannes Lohi, Kersten Lindblad-Toh and Tosso Leeb.

The phenotype (physical appearance) of the hairless dog’s in the Xolo line is classified as Canine Ectodermal Dysplasia. This is the near complete absence of hair and the effect on the teeth.Teeth and hair are classified as ectodermal appendages, because they form very late in the development of the fetus.  There are also some alterations in some of the exocrine glands in the human form which are not severe in the living dogs. This might also explain why some hairless dogs sweat through their skin because in this condition in humans the sweat glands can also be affected.

Ectodermal dysplasia in humans is a disorder involving two or more of the ectodermal structures, which include the skin, hair, nails, teeth, mucous membranes and sweat glands. How an individual is affected varies. For example, in one individual the hair and nails may be affected, while in another the disorder may involve the sweat glands and teeth. Each combination is considered a distinct type of ectodermal dysplasia.

They traced the gene to the 17th chromosome on the dogs where a sequence that is part of what is known as a FOX gene is duplicated. The Fox family of genes (which have nothing to do with foxes) are an important group of about 50 genes that encode for developmental regulators. This duplication is only 7 base pairs long but acts as an early “stop” signal for the production of the regulators. With only 1 gene the amount of the regulator is decreased but appears to be completely missing in the dogs with the two dominant genes. The lack of this regulator is thought to be the reason why the homozygous pups die.

The study was done using 140 hairless dogs, Chinese Crested, Xoloitzcuintle and Peruvians. The duplication was found in all of the dogs. When they tested coated dogs of the three breeds (55) and 32 other dogs from 19 other coated breeds there was no duplication on the gene.

They commented that “This study illustrated how the extreme morphological (body type) diversity of dogs can be harnessed to gain new insights into developmental biology.”

Kacie Johnson 
Tucson Arizona